Asymmetric Hydrocyanation of N ‐Phosphinoyl Aldimines with Acetone Cyanohydrin by Cooperative Lewis Acid/Onium Salt/Brønsted Base Catalysis
نویسندگان
چکیده
منابع مشابه
Bifunctional asymmetric catalysis: cooperative Lewis acid/base systems.
In the field of catalytic, asymmetric synthesis, there is a growing emphasis on multifunctional systems, in which multiple parts of a catalyst or multiple catalysts work together to promote a specific reaction. These efforts, in part, are result-driven, and they are also part of a movement toward emulating the efficiency and selectivity of nature's catalysts, enzymes. In this Account, we illust...
متن کاملRecent progress in Lewis acid–Lewis base bifunctional asymmetric catalysis*
Two enantioselective cyanation reactions, the Strecker reaction of ketoimines and the Reissert reaction of pyridine derivatives, promoted by Lewis acid–Lewis base bifunctional asymmetric catalysts are described.
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A binary catalyst system for the enantioselective bromocycloetherification of 5-arylpentenols is described. The combination of an achiral Lewis base and a chiral Brønsted acid affords good enantioselectivities for the cyclization of Z configured 5-arylpentenols to form bromomethyltetrahydrofurans. The constitutional site selectivity is highly dependent upon the aromatic substituent and the conf...
متن کاملLewis base catalysis in organic synthesis.
The legacy of Gilbert Newton Lewis (1875-1946) pervades the lexicon of chemical bonding and reactivity. The power of his concept of donor-acceptor bonding is evident in the eponymous foundations of electron-pair acceptors (Lewis acids) and donors (Lewis bases). Lewis recognized that acids are not restricted to those substances that contain hydrogen (Brønsted acids), and helped overthrow the "mo...
متن کامل1 Lewis Acid – Brønsted Base Catalysis
From the synthetic point of view, organic synthesis via catalytic processes offers many benefits. Catalysis frequently obviates the excessive use of the activating reagents and associated tedious purification processes, thereby offering more environmentally benign synthetic processes. Furthermore, the specific activation mode of a catalyst allows for highly chemoselective transformations that a...
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ژورنال
عنوان ژورنال: ChemCatChem
سال: 2021
ISSN: 1867-3880,1867-3899
DOI: 10.1002/cctc.202001921